研究業績

2023年

学術論文

• "T-shaped partial least squares for high-dosed new active pharmaceutical ingredients in continuous twin-screw wet granulation: Granule size prediction with limited material information"
  Kensaku Matsunami, Jonathan Meyer, Martin Rowland, Neil Dawson, Thomas De Beer, Daan Van Hauwermeiren
  International Journal of Pharmaceutics 646, 123481 (2023).

  • URL
  • DOI: 10.1016/j.ijpharm.2023.123481
• "Validation of model-based design of experiments for continuous wet granulation and drying"
  Kensaku Matsunami*, Tuur Vandeputte*, Ana Alejandra Barrera Jiménez, Michiel Peeters, Michael Ghijs, Daan Van Hauwermeiren, Fanny Stauffer, Eduardo dos Santos Schultz, Ingmar Nopens, Thomas De Beer (*shared first authorship)
  International Journal of Pharmaceutics 646, 123493 (2023).

  • URL
  • DOI: 10.1016/j.ijpharm.2023.123493
• "Development of concentration prediction models for personalized tablet manufacturing using near-infrared spectroscopy"
  Yusuke Hayashi, Saho Okazaki, Kensaku Matsunami, Kazuya Tanabe, Takuya Nagato, Hirokazu Sugiyama
  Chemical Engineering Research and Design 199, 507–514 (2023).

  • URL
  • DOI: 10.1016/j.cherd.2023.10.009
• "Exploring the effect of raw material properties on continuous twin-screw wet granulation manufacturability"
  Michiel Peeters, Ana Alejandra Barrera Jiménez, Kensaku Matsunami, Daan Van Hauwermeiren, Fanny Stauffer, Lærke Arnfast, Tamas Vigh, Ingmar Nopens, Thomas De Beer
  International Journal of Pharmaceutics 645, 123391 (2023).

  • URL
  • DOI: 10.1016/j.ijpharm.2023.123391
• "Partial least squares regression to calculate population balance model parameters from material properties in continuous twin-screw wet granulation"
  Ana Alejandra Barrera Jiménez*, Kensaku Matsunami*, Daan Van Hauwermeiren, Michiel Peeters, Fanny Stauffer, Eduardo dos Santos Schultz, Ashish Kumar, Thomas De Beer, Ingmar Nopens (*shared first authorship)
  International Journal of Pharmaceutics 640, 123040 (2023).

  • URL
  • DOI: 10.1016/j.ijpharm.2023.123040
• "Evaluation of the influence of material properties and process parameters on granule porosity in twin-screw wet granulation"
  Michiel Peeters, Ana Alejandra Barrera Jiménez, Kensaku Matsunami, Fanny Stauffer, Ingmar Nopens, Thomas De Beer
  International Journal of Pharmaceutics 641, 123010 (2023).

  • URL
  • DOI: 10.1016/j.ijpharm.2023.123010
• "Linking material properties to 1D-PBM parameters towards a generic model for twin-screw wet granulation"
  Ana Alejandra Barrera Jiménez*, Kensaku Matsunami*, Daan Van Hauwermeiren, Michiel Peeters, Fanny Stauffer, Eduardo dos Santos Schultz, Ashish Kumar, Thomas De Beer, Ingmar Nopens (*shared first authorship)
  Chemical Engineering Research and Design 193, 713–724 (2023).

  • URL
  • DOI: 10.1016/j.cherd.2023.04.009
• "Model development and calibration of two-dimensional population balance model for twin-screw wet granulation based on particle size distribution and porosity"
  Ana Alejandra Barrera Jiménez*, Kensaku Matsunami*, Michael Ghijs, Daan Van Hauwermeiren, Michiel Peeters, Fanny Stauffer, Thomas De Beer, Ingmar Nopens (*shared first authorship)
  Powder Technology 419, 118334 (2023).

  • URL
  • DOI: 10.1016/j.powtec.2023.118334
• "Surrogate modeling of dissolution behavior toward efficient design of tablet manufacturing processes"
  Kensaku Matsunami, Tomohiro Miura, Keita Yaginuma, Shuichi Tanabe, Sara Badr, Hirokazu Sugiyama
  Computers & Chemical Engineering 171, 108141 (2023).

  • DOI: 10.1016/j.compchemeng.2023.108141

招待講演

• "Application of mechanistic and data-driven models to continuous tablet manufacturing with knowledge of pharmaceutical science"
  Kensaku Matsunami
  第390回化学システム工学専攻公開セミナー, 東京大学大学院化学システム工学専攻, 東京都 (2023).

  • URL

国際学会

• "Uncertainty analysis of hybrid modeling: A case study of partial least squares and population balance model in continuous twin-screw wet granulation"
  (Oral) 〇Kensaku Matsunami, Ana Alejandra Barrera Jiménez, Thomas De Beer, Ingmar Nopens
  2023 AIChE Annual Meeting, 5–10 November 2023, Hyatt Regency, Orlando, USA (2023).
• "Model-based comparison of dissolution behavior between batch and continuous direct compression manufacturing platforms"
  (Oral) 〇Kensaku Matsunami, Remco Mariën, Valérie Vanhoorne, Thomas De Beer, Chris Vervaet, Ashish Kumar
  2023 AIChE Annual Meeting, 5–10 November 2023, Hyatt Regency, Orlando, USA (2023).

国内学会・シンポジウム

• "Model-Based Comparison of Dissolution Behavior between Batch and Continuous Direct Compression Manufacturing Platforms"
  (Poster) 〇Kensaku Matsunami, Remco Mariën, Alexander Ryckaert, Bram Bekaert, Valérie Vanhoorne, Thomas De Beer, Chris Vervaet, Ashish Kumar
  CESPE Conference 2023, 21 September 2023, Ghent, Belgium (2023).

  • URL